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June 16 2011 4 16 /06 /June /2011 08:11

Astigmatism is a very common vision condition that causes blurred vision due to the irregular shape of the cornea or the lens inside the eye. People with astigmatism experience headaches, fatigue, eyestrain, and blurred vision at all distances. Most astigmatism cases can be easily diagnosed and corrected. Learn about the causes, symptoms, diagnosis and treatment for astigmatism in this article.

Causes of astigmatism

An irregular shaped cornea or lens prevents light from focusing properly on the retina, resulting in blurry vision. Astigmatism occurs when the cornea is shaped more like an oblong football than a spherical baseball, which is the normal shape. A cornea with astigmatism has two curves, one flat curve and one that is steep. Light is thus focused at two points instead of one.

Regular versus irregular astigmatism

In regular astigmatism, the meridians in which the two different curves lie are located 90 degrees apart. In the case of irregular astigmatism, either the two meridians are not perpendicular or there are more than two meridians.

Lenticular astigmatism

Astigmatism caused by an irregularly shaped crystalline lens is called lenticular astigmatism. Usually, astigmatism is hereditary. However, astigmatism may also develop following an eye injury that has caused scarring on the cornea, or certain types of eye surgery. Keratoconus, a relatively rare condition that causes a gradual thinning of the cornea, may cause a large amount of astigmatism.

Astigmatism symptoms and diagnosis

Astigmatism causes vision to be blurred at both distance and near vision. Mild astigmatism may be asymptomatic and undetected, particularly in children. More severe astigmatism may cause eyestrain, fatigue, or headaches.

Detection and diagnosis

Astigmatism is easily detected through eye examination. A keratometer is usually used to measure the curvature of the cornea. A corneal topographer and a wavefront aberrometer may give much more precise information about astigmatism.

Astigmatism correction

Astigmatism may be corrected with glasses, contact lenses or surgery.

  • Glasses are the primary choice for people with small amount of astigmatism. Individuals with high amounts of astigmatism must have their glasses carefully adjusted to their face.
  • Contact lenses, such as 'toric contact lenses' can correct small amounts of astigmatism whereas severe astigmatism will be more successfully corrected with rigid astigmatism contact lenses as they maintain their regular shape while on the cornea.
  • Surgical vision correction procedure, such as photorefractive keratectomy and laser in situ keratomileusis, can also successfully correct astigmatism.

Conclusion

Astigmatism causes blurred vision that can be compensated with glasses or contact lenses or corrected with surgery. Astigmatism is easily detected through eye examination. A comprehensive eye examination should be scheduled when experiencing blurry vision at all distance, headaches or eyestrain.

Regular astigmatism schema
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June 15 2011 3 15 /06 /June /2011 15:23

Arthritis is a painful condition of the joints that refers to more than 100 different diseases. Approximately 350 million people worldwide are affected by arthritis. There are many treatment options depending on the type of arthritis and the patient. Learn about the causes of arthritis and how it can be treated.

What causes arthritis?

Arthritis is an illness of the joint. There are many forms of arthritis with over

100 different forms of the disease described so far. Some examples of such diseases are osteoarthritis, fibromyalgia, rheumatoid arthritis, gout arthritis, systemic lupus erythematosus, and juvenile arthritis. The causes of arthritis depend on the form of arthritis.

Causes include:

  • Injury leading to degenerative arthritis or degenerative joint disease.

  • Inheritance such as in familial Mediterranean fever.

  • Abnormal metabolism such as in gout arthritis.

  • Infection, such as in septic arthritis and arthritis of Lyme disease.

  • Autoimmune reaction, such as in rheumatoid arthritis and systemic lupus erythematosus.

How can arthritis be treated?

Treatment plans for arthritis depend on the type of arthritis and the patient. Arthritis causes a slow deterioration of the joints that can result in the complete deterioration of the cartilage. The goal of arthritis treatment is to reduce joint inflammation and pain, maintain joint function, prevent or minimise joint damage and deformities, and slow the progression of the disease.

Treatments of arthritis include:

  • Medications, such as NSAIDs (Non Steroidal Anti-Inflammatory Drugs) are used for treating arthritis. Aspirine is still one of the most effective anti-inflammatory medications available. Other drugs used for treating arthritis include the COX-2 inhibitors, corticosteroids and DMARDs (disease-modifying anti-rheumatic drugs).
  • Injections can be given locally into a joint. Viscosupplementation, a procedure that involves the injection of hyaluronates, or local steroid injections can be used.
  • Physical therapy and occupational therapy help to maintain joint mobility and daily activities. Exercise is essential to improve physical function and muscle strength. Devising a dietary plan is also important so as not to overstress the joints and for bone health.
  • Natural treatments, such as dietary supplements or acupuncture, are also used for treating arthritis.
  • Surgery may be necessary when joint damage is severe and when pain interferes with daily activities. It is usually the last resort option.

Final word

In conclusion, arthritis refers to many different individual diseases that involve joint damage and pain with different features and treatments. Appropriate treatment plans can help people with arthritis to live a normal life.

Knee joint
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June 7 2011 2 07 /06 /June /2011 18:51

Mercury poisoning from fish and dental amalgam fillings are most common. Acute mercury exposure is rare but results in immediate and severe symptoms. Chronic mercury poisoning is quite common and can also lead to serious damages to the health. Learn about the symptoms and treatment of the various forms of mercury poisoning.

Symptoms of mercury poisoning

Mercury exists in different forms: methylmercury, elemental mercury, organic and inorganic mercury. The effect on health depends on various factors, such as the health and age of the person exposed, the chemical form of mercury, the dose, duration and route of exposure.

Symptoms of methylmercury poisoning includes impairment of the peripheral vision, disturbances in sensations such as paresthesia, itching, burning or pain, lack of coordination of movements, impairment of speech, hearing, walking and muscle weakness. Methylmercury exposure is particularly damaging for the foetus during pregnancy.

Symptoms of elemental mercury poisoning include tremors, emotional changes, neuromuscular changes, headaches, disturbances in sensations, changes in nerve responses, and performance deficits on tests of cognitive function. At higher exposures of elemental mercury there may be kidney effects, respiratory failure and death. Liquid elemental mercury primarily causes health effects when it is inhaled as a vapour.

High exposures to inorganic mercury may result in damage to the gastrointestinal tract, the nervous system, and the kidneys. Organic mercury compounds are absorbed through the gastrointestinal tract. Symptoms of high exposures to inorganic mercury include kin rashes and dermatitis, mood swing, memory loss, mental disturbance and muscle weakness.

Treatment of mercury poisoning

In acute exposures, the first step in treatment is removing the mercury source and clothing. The contaminated person should also be thoroughly cleaned. Acute inhalation of mercury vapour may require emergency respiratory support.

Treatment varies with the form of mercury poisoning. Ingestion of an inorganic form of mercury usually begins with the removal of the source. Activated charcoal is used to bind and inactivate the toxin. Acute organic forms are treated with charcoal and a laxative. Ingestion of elemental mercury usually has no effects on gastrointestinal cells and is removed by a laxative. Medical treatment usually involves chelating agents, such as dimercaprol or DMSA, that bind most toxic forms.

In conclusion, symptoms of mercury poisoning are various and the extent of toxic effects depends on several factors. Mercury poisoning is usually difficult to treat and can lead to serious damages to the health and death.

Salmon
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May 31 2011 2 31 /05 /May /2011 14:28

Orphan diseases that affect a small percentage of the population or only in the developing world receive support and tax incentive for drug development. Learn about incentives to encourage drug development for orphan diseases.

What is an orphan disease? There is no widely accepted definition for orphan diseases. However, they fall into two categories: Rare diseases Diseases that affect small numbers of individuals. In the United States, any disease that affects fewer than 200,000 people is considered a rare disease whereas in Europe it is defined as a disease that occurs in less than 1 in 2,000 people. Neglected diseases Which are common diseases that have been ignored because they are far more prevalent in developing countries than in the developed world. Orphan diseases are diseases for which pharmaceutical companies are not interested in developing treatment due to the limited potential market and financial profit. To date, over 6,800 rare diseases have been reported and it is estimated that about 250 million people in the world suffer from rare diseases. Incentives to orphan drug development Initiative to develop products for orphan diseases came first from the Food and Drugs Administration with the creation of the Office of Orphan Products Development (OOPD) in 1983. This program has been very successful with more than 350 drugs and biological products brought to the market. The OOPD provides funding for clinical research and offers tax incentives on clinical trials. Similar legislation has been adopted in Japan and Australia. In 2000, The EU also adopted a legislation called “orphan medicinal product”. However, only diseases prevalent in the developing world were included and no tax incentive was proposed. To date, only 50 orphan drugs have been approved in Europe. In conclusion, regulatory and economic incentives for industry to develop orphan drugs have been globally successful, leading to the development of orphan products that could potentially treat 15 million patients.

References: Europa.eu

Orphan drug molecule
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